SCAPER蛋白抗体
规格：1mg/1ml
英文名： SCAPER
别名： FLJ31533; FLJ31953; FLJ46212; KIAA1454; MSTP063; S phase cyclin A-associated protein in the endoplasmic reticulum; S phase cyclin A-associated protein in the ER; SCAPE_HUMAN; SCAPER; Zfp291; Zinc fing
分子量： 158kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SCAPER
交叉反应：Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞核
SCAPER蛋白抗体产品介绍：background: SCAPER is a 1,399 amino acid protein that contains a C2H2-type zinc finger, a putative transmembrane domain, an ER retrieval signal at the C terminus, four coiled-coil domains, six potential RXL motifs that might confer binding to cyclins and six consensus Cdk phosphorylation sites. SCAPER interacts with, and is phosphorylated in vitro by, the cyclin A/Cdk2 complex at multiple phases of the cell cycle, including S and G2/M. It has been suggested that SCAPER represents a novel cyclin A/Cdk2 regulatory protein that transiently maintains cyclin A in the cytoplasm. The SCAPER protein is predominantly located in the endoplasmic reticulum, with only a small portion SCAPER蛋白抗体detected in the nucleus. Widely expressed, SCAPER demonstrates highest expression in testis. Existing as two alternatively spliced isoforms, the SCAPER gene is conserved in chimpanzee, dog, mouse, rat, chicken and zebrafish, and maps to human chromosome 15q24.3. Function: CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. Subcellular Location: Endoplasmic reticulum. SCAPER蛋白抗体Nucleus. Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus. Tissue Specificity: Widely expressed with highest expression in testis. Post-translational modifications: Phosphorylated in vitro by the CCNA2/CDK2 complex. Similarity: Contains 1 C2H2-type zinc finger. Database links: Entrez Gene: 49855 Human Entrez Gene: 244891 Mouse Omim: 611611 Human SwissProt: Q9BY12 Human Unigene: 458986 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SCAPER蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid