细胞色素P450ⅡE1抗体
规格：1mg/1ml
英文名： CYP2E1
别名： 4-nitrophenol 2-hydroxylase; CP2E1_HUMAN; CPE 1; CPE1; CYP2E; CYP2E1; CYP2E1; CYPIIE1; Cytochrome P450 2E1; cytochrome P450 family 2 subfamily E polypeptide 1; Cytochrome P450 isozyme 3A; Cytochrome P
分子量： 50-55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CYP2E1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
细胞色素P450ⅡE1抗体产品介绍：background: The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and biosynthesis. Cytochrome P450 2E1 is induced by ethanol, diabetes and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, and exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. Function: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. Subcellular Location:细胞色素P450ⅡE1抗体 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Tissue Specificity: Highest level in the liver and to a lesser extent in the kidney, with a higher level in the male kidney than in the female. Similarity: Belongs to the cytochrome P450 family. Gene ID: 1571 Database links: Entrez Gene: 1571 Human Entrez Gene: 13106 Mouse Entrez Gene: 25086 Rat 细胞色素P450ⅡE1抗体Omim: 124040 Human SwissProt: P05181 Human SwissProt: Q05421 Mouse SwissProt: P08682 Rabbit SwissProt: P05182 Rat Unigene: 12907 Human Unigene: 21758 Mouse Unigene: 1372 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 细胞色素P450 2E1(CYP2E1)可被乙醇等化合物诱导, 参与多种前致癌物(N-亚硝胺、苯胺、氯乙烯、氨基甲酸乙酯)的代谢活化,诱发肿瘤的发生。
细胞色素P450ⅡE1抗体产品应用：WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid