SAFB蛋白抗体
规格：1mg/1ml
英文名： SAFB
别名： DKFZP779C1727; HAP; HET; hsp27 ere tata binding; KIAA0138; SAF B; SAF B2; SAF-B2; SAFB; SAF-B; SAFB1; SAFB2; SAFB2_HUMAN; Scaffold attachment factor B2
分子量： 107kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SAFB
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆
SAFB蛋白抗体产品介绍：background: Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to pre-mRNA processing and transport. hnRNPs also bind heterogeneous nuclear RNA (hnRNA), the transcripts produced by RNA polymerase II. SAF-B (scaffold attachment factor B) is a nuclear matrix-associated protein that binds to matrix- or scaffold-associating regions (MARs or SARs) on DNA and interacts with RNA polymerase II and serine-/arginine-rich RNA processing factors (SR proteins). SAF-B, also designated HAP (hnRNP A1 associated protein) and HET (HSP 27-ERE-TATA-binding protein) is a proven hnRNP protein that has a speckled distribution in the nucleus and, in response to stress agents such as heat shock, is recruited to a few, large nuclear granules, called perichromatin granules.SAFB蛋白抗体 SAF-B also binds to the estrogen receptor (ER) and is expressed in several breast cancer cell lines at varying levels. Subsequently, SAF-B may play a role in breast cancer by mediating cellular proliferation and division. Function: Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines. Post-translational modifications: Phosphorylated SAFB蛋白抗体upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 RRM (RNA recognition motif) domain. Contains 1 SAP domain. Gene ID: 9667 Database links: Entrez Gene: 9667 Human Omim: 608066 Human SwissProt: Q14151 Human Unigene: 655392 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SAFB蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid