SAV1蛋白抗体
规格：1mg/1ml
英文名： SAV1
别名： 1700040G09Rik; 45 kDa WW domain protein; hWW 45; hWW45; Protein salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1; SAV 1; SAV; SAV1; SAV1_HUMAN; WW 45; WW domain containing; WW45
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SAV1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
SAV1蛋白抗体产品介绍：background: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in ***** tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012] Function: Regulator of MST1/MST2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatorySAV1蛋白抗体 protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for MST1/MST2 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Ubiquitously expressed in ***** tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the ***** heart. Expressed in various cell lines. Post-translational modifications: Phosphorylated SAV1蛋白抗体by STK3 and STK4. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule. Similarity: Contains 1 SARAH domain. Contains 2 WW domains. Gene ID: 60485 Database links: Entrez Gene: 60485 Human Entrez Gene: 64010 Mouse Entrez Gene: 299116 Rat Omim: 607203 Human SwissProt: Q9H4B6 Human SwissProt: Q8VEB2 Mouse SwissProt: A4V8B4 Rat Unigene: 642842 Human Unigene: 390480 Mouse Unigene: 14087 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SAV1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid