冠状病毒p65蛋白抗体
规格：1mg/1ml
英文名： SARS p65
别名： ORF1AB; p65 polyprotein; pp1ab; Replicase polyprotein 1ab.
分子量： 91kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SARS p65
交叉反应：Human, Reacts with SARS Coronavirus
细胞定位：
冠状病毒p65蛋白抗体产品介绍：background: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive stranded RNA approximately 27 to 31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin converting enzyme 2 (ACE2) on target cells. p65 is the replicase polyprotein of coronaviruses, and is a multifunctional protein. It contains the activities necessary for the transcription of negative stranded RNA, 冠状病毒p65蛋白抗体leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products. It is responsible for the cleavages located at the N terminus of replicase polyprotein and its activity is dependent on zinc. p65 exists as monomer and homodimer. The Cys rich growth factor like peptide forms a homodimer. The hydrophobic domains (HD) could 冠状病毒p65蛋白抗体mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane. p65 is translated as a 1a-1b polyprotein by a ribosomal frameshifting mechanism. The 1A polyprotein is produced by itself but not the 1B polyprotein. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
冠状病毒p65蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid