碘酪氨酸脱碘酶抗体
规格：1mg/1ml
英文名： IYD
别名： C6orf71; DEHAL1; dJ422F24.1; Iodotyrosine dehalogenase 1; iodotyrosine deiodinase; IYD; IYD-1; IYD1_HUMAN; OTTHUMP00000017973; OTTHUMP00000237263; OTTHUMP00000237264; OTTHUMP00000237265; OTTHUMP000002
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IYD
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
碘酪氨酸脱碘酶抗体产品介绍：background: This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] Function: Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. 碘酪氨酸脱碘酶抗体Acts more efficiently on monoiodotyrosine than on diiodotyrosine. Subcellular Location: Cell membrane. Tissue Specificity: Expressed at a high level in thyroid gland and at lower level in kidney and trachea. DISEASE: Defects in IYD are the cause of congenital hypothyroidism due to dyshormonogenesis type 4 (CHDH4) [MIM:274800]; also known as genetic defect in thyroid hormonogenesis type 4 or iodotyrosine dehalogenase deficiency or deiodinase deficiency. Patients with this defect present a phenotype of severe hypothyroidism, goiter, excessive levels 碘酪氨酸脱碘酶抗体of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized hypothyroidism. Similarity: Belongs to the nitroreductase family. Gene ID: 389434 Database links: Entrez Gene: 389434 Human Entrez Gene: 70337 Mouse Entrez Gene: 308129 Rat Omim: 612025 Human SwissProt: Q6PHW0 Human SwissProt: Q9DCX8 Mouse SwissProt: Q5BK17 Rat Unigene: 310225 Human Unigene: 24153 Mouse Unigene: 34836 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
碘酪氨酸脱碘酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid