硫嘌呤甲基转移酶抗体
规格：1mg/1ml
英文名： TPMT
别名： HGNC:12014; S adenosyl L methionine thiopurine S methyltransferase; Thiopurine methyltransferase; Thiopurine S methyltransferase; Thiopurine S-methyltransferase; TPMT; TPMT_HUMAN.
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TPMT
交叉反应：Human,
细胞定位：细胞浆
硫嘌呤甲基转移酶抗体产品介绍：background: This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] Function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Subcellular Location: Cytoplasm. DISEASE: Defects in TPMT are the cause 硫嘌呤甲基转移酶抗体of thiopurine S-methyltransferase deficiency (TPMT deficiency) [MIM:610460]. TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus. Similarity: Belongs to the methyltransferase superfamily. TPMT family. Gene ID: 7172 Database links: Entrez Gene: 7172 Human Entrez Gene: 22017 Mouse Entrez Gene: 690050 Rat Omim: 187680 Human SwissProt: P51580 Human SwissProt: 硫嘌呤甲基转移酶抗体O55060 Mouse SwissProt: Q9Z0T0 Rat Unigene: 444319 Human Unigene: 10169 Mouse Unigene: 112598 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TPMT是硫嘌呤类**（如硫唑嘌呤、巯嘌呤和硫鸟嘌呤）的代谢中*主要的酶之一，起到的作用是在这类化合物的硫原子上增加一个甲基；这个过程中提供甲基的是S-腺苷甲硫氨酸，后者同时被转化成S-腺苷-L-高半胱氨酸。 TPMT基因的缺陷会让人体无法将这类**灭活，未代谢的**因此在体内大量累积，从而引起严重甚至致命的骨髓抑制，表现为贫血、血小板减少症（导致出血）和白细胞减少症（导致感染）等.
硫嘌呤甲基转移酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid