原肌球蛋白调节蛋白3抗体
规格：1mg/1ml
英文名： Tropomodulin 3
别名： OTTHUMP00000162615; Tmod3; TMOD3_HUMAN; Tropomodulin 3 (ubiquitous); Tropomodulin 3 ubiquitous; Tropomodulin-3; U Tmod; U-Tmod; Ubiquitous tropomodulin; UTmod.
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Tropomod
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
原肌球蛋白调节蛋白3抗体产品介绍：background: Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of Actin filaments. A component of the membrane skeleton, tropomodulin binds to the amino-terminus of Tropomyosin, which coats the surface of Actin, and thus blocks the elongation and depolymerization of Actin filaments. Four tropomodulin isoforms, tropomodulin 1-4, have been characterized in humans. Tropomodulin expression is isoform-specific; tropomodulin 3 is expressed ubiquitously, whereas tropomodulin 2 and tropomodulin 4 are expressed in neuronal tissue and muscle, respectively. Ubiquitous expression of seven tropomodulin 3 transcripts, ranging in size between 1 and 9.5 kb, have been identified by Northern Blot analysis on human tissues. The human TMOD3 gene maps to chromosome 15q21.2, within the same region as the gene for amyotrophic lateral sclerosis 5 (ALS5), and encodes a 352 amino acid protein. Tmod3,原肌球蛋白调节蛋白3抗体 the mouse homolog to human TMOD3, is present as early as day 7 in embryonic development and is expressed throughout development. Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. Subunit: Binds to the N-terminus 原肌球蛋白调节蛋白3抗体of tropomyosin and to actin. Subcellular Location: Cytoplasm > cytoskeleton. Tissue Specificity: Ubiquitous. Similarity: Belongs to the tropomodulin family. Gene ID: 29766 Database links: Entrez Gene: 29766 Human Entrez Gene: 50875 Mouse Entrez Gene: 397556 Pig Entrez Gene: 300838 Rat Omim: 605112 Human SwissProt: Q9NYL9 Human SwissProt: Q9JHJ0 Mouse Unigene: 4998 Human Unigene: 38445 Mouse Unigene: 146101 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
原肌球蛋白调节蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 结合蛋白 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid