甲状腺受体相互作用蛋白6抗体
规格：1mg/1ml
英文名： TRIP6
别名： MGC10556; MGC10558; MGC29959; MGC3837; MGC4423; OIP-1; OIP1; OPA interacting protein 1; OPA-interacting protein 1; Thyroid hormone receptor interactor 6; Thyroid receptor interacting protein 6; Thyroi
分子量： 50kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRIP6
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
甲状腺受体相互作用蛋白6抗体产品介绍：background: This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] Function: Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN,甲状腺受体相互作用蛋白6抗体 and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. Subcellular Location: Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm. Tissue Specificity: Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors甲状腺受体相互作用蛋白6抗体. Post-translational modifications: Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13. Similarity: Belongs to the zyxin/ajuba family. Contains 3 LIM zinc-binding domains. Gene ID: 7205 Database links: Entrez Gene: 7205 Human Entrez Gene: 22051 Mouse Omim: 602933 Human SwissProt: Q15654 Human SwissProt: Q9Z1Y4 Mouse Unigene: 534360 Human Unigene: 27063 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
甲状腺受体相互作用蛋白6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid