细胞表面趋化因子受体10抗体
规格：1mg/1ml
英文名： CCR10
别名： C-C chemokine receptor 10; C C chemokine receptor type 10; C C CKR 10; CC chemokine receptor 10; CC CKR 10; CCR 10; CCR-10; CCR10; Chemokine (C C motif) receptor 10; G protein coupled receptor 2; G pr
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CCR-10 (
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞膜
细胞表面趋化因子受体10抗体产品介绍：background: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM,细胞表面趋化因子受体10抗体 Mar 2008] Function: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed at high levels in ***** testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other ***** tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also细胞表面趋化因子受体10抗体 expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 2826 Database links: Entrez Gene: 2826 Human Entrez Gene: 12777 Mouse Omim: 600240 Human SwissProt: P46092 Human SwissProt: Q9JL21 Mouse Unigene: 278446 Human Unigene: 103813 Mouse Unigene: 8021 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞表面趋化因子受体10抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid