组蛋白乙酰转移酶MORF抗体
规格：1mg/1ml
英文名： KAT6B
别名： DKFZp313G1618; FLJ90335; Histone acetyltransferase MORF; Histone acetyltransferase MOZ2; Histone acetyltransferase MYST4; KAT 6B; KIAA0383; Monocytic leukemia zinc finger protein related factor; Monoc
分子量： 230kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KAT6B
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞核
组蛋白乙酰转移酶MORF抗体产品介绍：background: The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] Function: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription.组蛋白乙酰转移酶MORF抗体 Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary. Post-translational modifications: Autoacetylated. DISEASE: Note=A chromosomal aberration involving组蛋白乙酰转移酶MORF抗体 MYST4 may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP. Similarity: Belongs to the MYST (SAS/MOZ) family. Contains 1 C2HC-type zinc finger. Contains 1 H15 (linker histone H1/H5 globular) domain. Contains 2 PHD-type zinc fingers. Gene ID: 23522 Database links: Entrez Gene: 23522 Human Omim: 605880 Human SwissProt: Q8WYB5 Human Unigene: 35758 Human Unigene: 599543 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白乙酰转移酶MORF抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid