组蛋白乙酰基转移酶GCN5抗体
规格：1mg/1ml
英文名： KAT2A/GCN5
别名： 1110051E14Rik; AW212720; EC 2.3.1.48; GCN 5; GCN5 (general control of amino acid synthesis yeast homolog) like 2; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; Gcn5; GCN5 gene
分子量： 94kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KAT2A/GC
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
组蛋白乙酰基转移酶GCN5抗体产品介绍：background: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009] Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles.组蛋白乙酰基转移酶GCN5抗体 In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Subcellular Location: Nucleus. Tissue Specificity: Expressed in all tissues tested, with most abundant expression in ovary. 组蛋白乙酰基转移酶GCN5抗体Similarity: Belongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain. Gene ID: 2648 Database links: Entrez Gene: 2648 Human Entrez Gene: 14534 Mouse Omim: 602301 Human SwissProt: Q92830 Human SwissProt: Q9JHD2 Mouse Unigene: 463045 Human Unigene: 218837 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白乙酰基转移酶GCN5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid