钾离子通道蛋白Kir7.1抗体
规格：1mg/1ml
英文名： Kir7.1
别名： Inward rectifier K(+) channel Kir7.1; Inward rectifier potassium channel 13; inwardly rectifying subfamily J member 13; IRK13_HUMAN; KCNJ13; KIR1.4; KIR7.1; LCA16; Potassium channel; Potassium inwardl
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Kir7.1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
钾离子通道蛋白Kir7.1抗体产品介绍：background: This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associated with snowflake vitreoretinal degeneration. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.钾离子通道蛋白Kir7.1抗体 KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. Subcellular Location: Membrane. Tissue Specificity: Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord. DISEASE: Defects in KCNJ13 are the cause of snowflake vitreoretinal degeneration (SVD) [MIM:193230]. SVD is a developmental and progressive hereditary eye disorder that affects multiple tissues within the eye. Diagnostic features of SVD include fibrillar degeneration of the vitreous humor, early-onset钾离子通道蛋白Kir7.1抗体 cataract, minute crystalline deposits in the neurosensory retina, and retinal detachment. Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ13 subfamily. Database links: Entrez Gene: 3769 Human Entrez Gene: 100040591 Mouse Entrez Gene: 94341 Rat Omim: 603208 Human SwissProt: O60928 Human SwissProt: P86046 Mouse SwissProt: O70617 Rat Unigene: 467338 Human Unigene: 443539 Mouse Unigene: 14516 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钾离子通道蛋白Kir7.1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 通道蛋白 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid