钾离子通道KIR2.3抗体
规格：1mg/1ml
英文名： KIR2.3
别名： Hippocampal inward rectifier; Hippocampal inward rectifier potassium channel; HIR; HIRK2; HRK1; Inward rectifier K(+) channel Kir2.3; Inward rectifier K+ channel Kir2.3; Inward rectifier potassium cha
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KIR2.3
交叉反应：Human,
细胞定位：细胞膜
钾离子通道KIR2.3抗体产品介绍：background: Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the 钾离子通道KIR2.3抗体cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Subcellular Location: Cell membrane. Cytoplasmic vesicle membrane. TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization. Tissue Specificity: Heart, skeletal muscle,钾离子通道KIR2.3抗体 and several different brain regions including the hippocampus. Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily. Gene ID: 3761 Database links: Entrez Gene: 3761 Human Entrez Gene: 16520 Mouse Entrez Gene: 116649 Rat Omim: 600504 Human SwissProt: P48050 Human SwissProt: P52189 Mouse SwissProt: P52190 Rat Unigene: 32505 Human Unigene: 140760 Mouse Unigene: 10197 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钾离子通道KIR2.3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 通道蛋白 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit