驱动蛋白家族成员20B抗体
规格：1mg/1ml
英文名： KIF20B
别名： Cancer/testis antigen 90; CT90; KI20B_HUMAN; KIF20B; Kinesin-like protein KIF20B; Kinesin-related motor interacting with PIN1; KRMP1; M-phase phosphoprotein 1; MPHOSPH1; MPP 1; Mpp1.
分子量： 210kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KIF20B
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆
驱动蛋白家族成员20B抗体产品介绍：background: The Kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual Kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events, including endocytosis and transcytosis. MPP1 (M-phase phosphoprotein 1), also known as KIF20B (kinesin family member 20B), MPHOSPH1 or KRMP1, is a 1,820 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one kinesin-motor domain. Expressed in kidney, brain, testis and ovary, MPP1 functions as a plus-end directed motor enzyme that interacts with Pin1 and is required for the completion of cytokinesis. MPP1, which exists as multiple alternatively spliced 驱动蛋白家族成员20B抗体isoforms termed 1-5, is subject to post-translational phosphorylation, probably by ATM or ATR. Function: Plus-end-directed motor enzyme that is required for completion of cytokinesis. Subcellular Location: Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > spindle. Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules. A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase驱动蛋白家族成员20B抗体 accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the mid-body. Tissue Specificity: Brain, ovary, kidney and testis. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain. Gene ID: 9585 Database links: Entrez Gene: 9585 Human Omim: 605498 Human SwissProt: Q96Q89 Human Unigene: 240 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
驱动蛋白家族成员20B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid