磷酸化有丝分裂驱动蛋白样2抗体
规格：1mg/1ml
英文名： phospho-KIF20A (Ser528)
别名： KIF20A (phospho S528); p-KIF20A (phospho S528); GG10 2; GG10_2; Kif20a; kinesin family member 20A; Kinesin like protein KIF20A; Kinesin-like protein 174; mitotic kinesin like protein 2; MKLP2; RAB6 in
分子量： 100kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Rat,
细胞定位：细胞浆
磷酸化有丝分裂驱动蛋白样2抗体产品介绍：background: The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell (1-3). Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis (3,4). KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons (5). Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle (5). Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum (5). KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta (6).磷酸化有丝分裂驱动蛋白样2抗体 In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance (7). Function: Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. Subcellular Location磷酸化有丝分裂驱动蛋白样2抗体: Golgi apparatus. Cytoplasm > cytoskeleton > spindle. Post-translational modifications: Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle. Similarity: Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain. Gene ID: 10112 Database links: Entrez Gene: 10112 Human Entrez Gene: 19348 Mouse Omim: 605664 Human SwissProt: O95235 Human SwissProt: P97329 Mouse Unigene: 718626 Human Unigene: 258846 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化有丝分裂驱动蛋白样2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid