信号通路Wnt3a抗体
规格：1mg/1ml
英文名： Wnt3a
别名： MGC119418; MGC119419; MGC119420; Protein Wnt 3a Precursor; Protein Wnt-3a; Wingless type MMTV integration site family member 3A; Wnt 3a; WNT3A protein.
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Wnt3a
交叉反应：Human, Mouse, Rat, Pig,
细胞定位：细胞外基质 分泌型蛋白
信号通路Wnt3a抗体产品介绍：background: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008] Function: Ligand for members of the frizzled family of信号通路Wnt3a抗体 seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. Subunit: Interacts with PORCN. Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6. Subcellular Location: Secreted, extracellular space, extracellular信号通路Wnt3a抗体 matr Tissue Specificity: Moderately expressed in placenta and at low levels in ***** lung, spleen, and prostate. Post-translational modifications: Palmitoylation at Ser-209 by PORCN is required for proper trafficking to cell surface, vacuolar acidification is critical to release palmitoylated WNT3A from WLS in secretory vesicles. Similarity: Belongs to the Wnt family. Gene ID: 89780 Database links: Entrez Gene: 89780 Human Entrez Gene: 22416 Mouse Entrez Gene: 303181 Rat Omim: 606359 Human SwissProt: P56704 Human SwissProt: P27467 Mouse Unigene: 336930 Human Unigene: 1367 Mouse Unigene: 130971 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Wnt3a是Wnt家族的成员之一,对神经干细胞的增殖及分化有一定的调控作用,Wnt3a蛋白可以促进神经干细胞向神经元分化.
信号通路Wnt3a抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 干细胞 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid