肿瘤细胞调亡素/死亡受体5抗体
规格：1mg/1ml
英文名： DR5
别名： sTRAIL Receptor 2; Death receptor 5; CD 262; CD262; CD262 antigen; Death domain containing receptor for TRAIL/Apo2L; Death receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; p53 re
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from rat DR5
交叉反应：Mouse, Rat,
细胞定位：细胞膜
肿瘤细胞调亡素/死亡受体5抗体产品介绍：background: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation 肿瘤细胞调亡素/死亡受体5抗体of NF-kappa-B. Essential for ER stress-induced apoptosis. Subcellular Location: Cell Membrane Tissue Specificity: Widely expressed in ***** and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. DISEASE: Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.肿瘤细胞调亡素/死亡受体5抗体 Note=The disease may be caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 death domain. Contains 3 TNFR-Cys repeats. Gene ID: 364420 Database links: Entrez Gene: 8795 Human Entrez Gene: 21933 Mouse Entrez Gene: 364420 Rat Omim: 603612 Human SwissProt: O14763 Human SwissProt: Q9QZM4 Mouse Unigene: 521456 Human Unigene: 193430 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DR5分布比较广泛，包括肝、脾、肺、胸腺和活化T细胞以及一些肿瘤细胞系。APO-2L在诱导转化细胞和肿瘤细胞的调亡中，广泛且迅速，多表达与胞浆。
肿瘤细胞调亡素/死亡受体5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 细胞凋亡 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid