KHSRP蛋白抗体
规格：1mg/1ml
英文名： KHSRP
别名： Far upstream element-binding protein 2; FBP2; FUBP2; FUBP2_HUMAN; FUSE binding protein 2; FUSE-binding protein 2; KH type splicing regulatory protein (FUSE binding protein 2); KH type splicing regulat
分子量： 74kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KHSRP
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse,
细胞定位：细胞核 细胞浆
KHSRP蛋白抗体产品介绍：background: The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010] Function: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream KHSRP蛋白抗体element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. Subcellular Location: Nucleus.KHSRP蛋白抗体 Cytoplasm. A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. Tissue Specificity: Detected in neural and non-neural cell lines. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the KHSRP family. Contains 4 KH domains. Gene ID: 8570 Database links: Entrez Gene: 8570 Human Entrez Gene: 16549 Mouse Entrez Gene: 171137 Rat Omim: 603445 Human SwissProt: Q92945 Human SwissProt: Q3U0V1 Mouse SwissProt: Q99PF5 Rat Unigene: 726172 Human Unigene: 34296 Mouse Unigene: 92643 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KHSRP蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid