信号转导相关蛋白3抗体
规格：1mg/1ml
英文名： KHDRBS3
别名： Etle; etoile; KH domain containing RNA binding signal transduction associated 3; KH domain containing RNA binding signal transduction associated protein 3; KH domain-containing; KHDR3_HUMAN; Khdrbs3;
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KHDRBS3
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
信号转导相关蛋白3抗体产品介绍：background: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Function: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved vitro. Subunit: Self-associates to form homooligomers. Subcellular Location: Nucleus. Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one. 信号转导相关蛋白3抗体Tissue Specificity: Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis. Post-translational modifications: Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated. Similarity: Belongs to 信号转导相关蛋白3抗体the KHDRBS family. Contains 1 KH domain. Gene ID: 10656 Database links: Entrez Gene: 10656 Human Entrez Gene: 13992 Mouse Entrez Gene: 64015 Rat Omim: 610421 Human SwissProt: O75525 Human SwissProt: Q9R226 Mouse SwissProt: Q9JLP1 Rat Unigene: 444558 Human Unigene: 17964 Mouse Unigene: 54682 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
信号转导相关蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid