电压门控钾通道Kv8.2抗体
规格：1mg/1ml
英文名： KCNV2
别名： KCNV2; KCNV2_HUMAN; KV11.1; Kv8.2; MGC120515; Potassium channel subfamily V member 2; Potassium voltage-gated channel subfamily V member 2; RCD3B; Voltage-gated potassium channel Kv8.2; Voltage-gated
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KCNV2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
电压门控钾通道Kv8.2抗体产品介绍：background: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008] Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more电压门控钾通道Kv8.2抗体 negative values. Subunit: Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers. Subcellular Location: Cell membrane. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1. Tissue Specificity: Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon. DISEASE: Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B) [MIM:610356]; also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and电压门控钾通道Kv8.2抗体, later, more obvious areas of atrophy. Similarity: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily. Gene ID: 169522 Database links: Entrez Gene: 169522 Human Entrez Gene: 240595 Mouse Omim: 607604 Human SwissProt: Q8TDN2 Human SwissProt: Q8CFS6 Mouse Unigene: 624689 Human Unigene: 660831 Human Unigene: 269759 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
电压门控钾通道Kv8.2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid