环化核苷酸调控阳离子通道蛋白亚型4
规格：1mg/1ml
英文名： HCN4
别名： HCN 4;Hyperpolarization activated cyclic nucleotide gated potassium channel 4; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 4;Hyperpolarization activated Cyclic Nucleot
分子量： 129kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HCN4
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：细胞膜
环化核苷酸调控阳离子通道蛋白亚型4产品介绍：background: HCN4 is a member of the family of hyperpolarization activated and cyclic nucleotide gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node. Function: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli. Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus. DISEASE: Defects in HCN4 are a cause 环化核苷酸调控阳离子通道蛋白亚型4of sick sinus syndrome type 2 (SSS2) [MIM:163800]; also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors, in which case it is considered to be a congenital disorder. Defects in HCN4 are the cause of Brugada syndrome type 环化核苷酸调控阳离子通道蛋白亚型48 (BRGDA8) [MIM:613123]. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset Similarity: Belongs to the potassium channel HCN family. Contains 1 cyclic nucleotide-binding domain. Gene ID: 10021 Database links: Entrez Gene: 10021 Human Entrez Gene: 330953 Mouse Entrez Gene: 59266 Rat Omim: 605206 Human SwissProt: Q9Y3Q4 Human SwissProt: O70507 Mouse SwissProt: Q9JKA7 Rat Unigene: 86941 Human Unigene: 41082 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. HCN4阳离子通道结构蛋白,具有调节心脏起搏的功能蛋白。
环化核苷酸调控阳离子通道蛋白亚型4产品应用：WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 **学 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid