电压门控钾通道亚基Kv7.3抗体
规格：1mg/1ml
英文名： KCNQ3
别名： BFNC 2; BFNC; BFNC2; EBN 2; EBN2; KCNQ 3; KCNQ3; KCNQ3_HUMAN; KQT like 3; KQT-like 3; KV7.3; Potassium channel subunit alpha KvLQT3; Potassium channel voltage gated subfamily Q member 3; Potassium vol
分子量： 97kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KCNQ3
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：细胞膜
电压门控钾通道亚基Kv7.3抗体产品介绍：background: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found. [provided by RefSeq, Mar 2011] Function: Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a电压门控钾通道亚基Kv7.3抗体potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Subcellular Location: Membrane. Tissue Specificity: Predominantly expressed in brain. DISEASE: Defects in KCNQ3 are the cause of benign neonatal epilepsy type 2 (EBN2) [MIM:121201]. Benign neonatal epilepsy is characterized by clusters of seizures occurring in电压门控钾通道亚基Kv7.3抗体 the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. Similarity: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily. Gene ID: 3786 Database links: Entrez Gene: 3786 Human Entrez Gene: 110862 Mouse Entrez Gene: 29682 Rat Omim: 602232 Human SwissProt: O43525 Human SwissProt: Q8K3F6 Mouse SwissProt: O88944 Rat Unigene: 374023 Human Unigene: 255585 Mouse Unigene: 205060 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
电压门控钾通道亚基Kv7.3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid