钙激活钾通道蛋白β4抗体
规格：1mg/1ml
英文名： KCNMB4
别名： BK channel subunit beta 4; BK channel subunit beta-4; BKbeta4; Calcium activated potassium channel beta 4 subunit; Calcium activated potassium channel subfamily M subunit beta 4; Calcium activated pot
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KCNMB4
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞膜
钙激活钾通道蛋白β4抗体产品介绍：background: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008] Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.钙激活钾通道蛋白β4抗体 Subcellular Location: Membrane. Tissue Specificity: Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues. Post-translational modifications: Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics. N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin. Similarity: Belongs to the KCNMB (TC 8.A.14.1) 钙激活钾通道蛋白β4抗体family. KCNMB4 subfamily. Gene ID: 27345 Database links: Entrez Gene: 27345 Human Entrez Gene: 58802 Mouse Entrez Gene: 66016 Rat Omim: 605223 Human SwissProt: Q86W47 Human SwissProt: Q9JIN6 Mouse SwissProt: Q9ESK8 Rat Unigene: 525529 Human Unigene: 440652 Mouse Unigene: 162953 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙激活钾通道蛋白β4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid