钙激活钾通道蛋白β3抗体
规格：1mg/1ml
英文名： KCNMB3
别名： BK channel subunit beta 3; BKbeta 3; BKbeta3; Calcium activated potassium channel beta 3 subunit; Calcium activated potassium channel subfamily M subunit beta 3; Calcium activated potassium channel su
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KCNMB3
交叉反应：Human,
细胞定位：细胞膜
钙激活钾通道蛋白β3抗体产品介绍：background: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009] Function: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels composed of the pore-forming alpha subunit and in some tissues a modulatory beta subunit.钙激活钾通道蛋白β3抗体 MaxiK cahannels are fundamental to the control of smooth muscle tone and neuronal excitability. KCNMB3 is a regulatory beta subunit of the MaxiK channel. It modulates the calcium sensitivity and gating kinetics of MaxiK thereby contributing to channel diversity. Subcellular Location: Membrane. Multi-pass membrane protein. Tissue Specificity: Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis. Post-translational modifications:钙激活钾通道蛋白β3抗体 N-glycosylated. The extracellular domain contains disulfide bond essential for the gating mechanism. Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily. Gene ID: 27094 Database links: Entrez Gene: 27094 Human Entrez Gene: 435726 Mouse Entrez Gene: 310303 Rat Omim: 605222 Human SwissProt: Q9NPA1 Human SwissProt: A7VL23 Rat Unigene: 591285 Human Unigene: 218452 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙激活钾通道蛋白β3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid