A型钾离子通道调节蛋白1抗体
规格：1mg/1ml
英文名： KCNIP1
别名： A type potassium channel modulatory protein 1; KChIP1; KCIP1_HUMAN; Kcnip1; Kv channel interacting protein 1; MGC9; MGC95; Potassium channel interacting protein 1; VABP; Vesicle APC binding protein.
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KCNIP1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
A型钾离子通道调节蛋白1抗体产品介绍：background: This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivationA型钾离子通道调节蛋白1抗体 in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface. Subcellular Location: Cell membrane. Tissue Specificity: Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus. Similarity: Belongs to the recoverin family. Contains 4 EF-hand domains. Gene ID: 30820 DatabaseA型钾离子通道调节蛋白1抗体 links: Entrez Gene: 30820 Human Entrez Gene: 70357 Mouse Entrez Gene: 65023 Rat Omim: 604660 Human SwissProt: Q9NZI2 Human SwissProt: Q9JJ57 Mouse SwissProt: Q8R426 Rat Unigene: 484111 Human Unigene: 252514 Mouse Unigene: 20530 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
A型钾离子通道调节蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 通道蛋白 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid