驱动蛋白家族成员18B抗体
规格：1mg/1ml
英文名： KIF18B
别名： Kinesin family member 18B; KI18B_HUMAN; Kinesin-like protein KIF18B.
分子量： 94kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KIF18B
交叉反应：Human, Mouse, Rat, Chicken, Horse, Chimpanzee, Cynomolgus Monkey, Macaque Monkey, Rhesus monkey, Gorilla, O
细胞定位：细胞核 细胞浆
驱动蛋白家族成员18B抗体产品介绍：background: The Kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual Kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events, including endocytosis and transcytosis. KIF18B (kinesin family member 18B) is an 864 amino acid nuclear and cytoplasmic protein that belongs to the kinesin-like protein family. Containing one kinesin-motor domain, KIF18B is dominantly expressed in amygdala. During mitosis, KIF18B is suggested to be closely associated with astral microtubules emanating from the spindle pole during prometaphase and metaphase. KIF18B may play an important role in regulating cell division. KIF18B 驱动蛋白家族成员18B抗体exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 17q21.31. Function: May play an important role in regulating cell division. Subunit: Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding. Subcellular Location:驱动蛋白家族成员18B抗体 Cytoplasmic, Nuclear and Plasma membrane Tissue Specificity: Shows a prominent expression in the amygdala. Similarity: Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain. Gene ID: 146909 Database links: Entrez Gene: 146909 Human Omim: 614570 Human SwissProt: Q86Y91 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
驱动蛋白家族成员18B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid