KYNU蛋白抗体
规格：1mg/1ml
英文名： KYNU
别名： kynU; KYNU_HUMAN; kynureninase (L-kynurenine hydrolase); Kynureninase; L-kynurenine hydrolase.
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KYNU
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
KYNU蛋白抗体产品介绍：background: Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] Function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle,KYNU蛋白抗体 kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. DISEASE: Note=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiencyKYNU蛋白抗体 and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. Similarity: Belongs to the kynureninase family. Gene ID: 8942 Database links: Entrez Gene: 8942 Human Entrez Gene: 70789 Mouse Entrez Gene: 116682 Rat Omim: 605197 Human SwissProt: Q16719 Human SwissProt: Q9CXF0 Mouse SwissProt: P70712 Rat Unigene: 470126 Human Unigene: 105278 Mouse Unigene: 10575 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KYNU蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid