AF6蛋白抗体
规格：1mg/1ml
英文名： l Afadin
别名： AF 6; AF6; AFAD_HUMAN; Afadin; ALL1-fused gene from chromosome 6 protein; FLJ34371; MLLT 4; MLLT4; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog Drosophila) translocated to 4; Myeloid/
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human l Afadin
交叉反应：Human, Mouse, Rat, Chicken, Zebrafish, Firefly,
细胞定位：
AF6蛋白抗体产品介绍：background: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011] Function: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. Subcellular Location: Cell junction > AF6蛋白抗体adherens junction. Not found at cell-matrix AJs. DISEASE: Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein. Similarity: Contains 1 dilute domain. Contains 1 FHA domain. Contains 1 PDZ (DHR) domain. Contains 2 Ras-associating domains. Gene ID: 4301 Database links: Entrez Gene: 421564 Chicken Entrez Gene: AF6蛋白抗体4301 Human Entrez Gene: 17356 Mouse Entrez Gene: 26955 Rat Omim: 159559 Human SwissProt: P55196 Human SwissProt: Q9QZQ1 Mouse SwissProt: O35889 Rat Unigene: 614974 Human Unigene: 644024 Human Unigene: 708726 Human Unigene: 728849 Human Unigene: 59167 Mouse Unigene: 58 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
AF6蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 结合蛋白 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid