C-SKI抗体
规格：1mg/1ml
英文名： SKI
别名： C-SKI; v-SKI; Sloan-kettering viral oncogene homolog; Avian sarcoma viral (v ski) oncogene homolog; C oncogene; C ski; Ski oncogene; Ski oncoprotein; SKV; v ski avian sarcoma viral oncogene homolog; v
分子量： 80kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C-SKI
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
细胞定位：细胞核
C-SKI抗体产品介绍：background: SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as C-SKI抗体c-myc. Function: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. Subunit: Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes. Subcellular Location: Nucleus. Similarity: Belongs to the SKI family. Gene ID: 6497 Database links: Entrez GeneC-SKI抗体 6497 Human Entrez Gene: 20481 Mouse Omim: 164780 Human SwissProt: P49140 Chicken SwissProt: P12755 Human SwissProt: Q60698 Mouse Unigene: 656507 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SKI又称SKI、SKV，经研究发现SKI蛋白是刺激和诱发肿瘤生长导致癌症的关键蛋白质之一，SKI蛋白主要通过阻止TGF-β蛋白发挥作用,当TGF-β蛋白的信号传导被SKI蛋白阻断后，细胞就可能加速增值、生长，*终导致癌症发生。 有研究表明：c-ski可调节多种核因子的转录活性,参与神经系统发育、造血细胞的增殖和分化、肿瘤发生、组织再生等多种生理病理过程，更详细的作用机制还在进一步研究之中。
C-SKI抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid