细胞角蛋白74抗体
规格：1mg/1ml
英文名： KRT74
别名： CK-74; Cytokeratin-74; K2C74_HUMAN; K5C; K6IRS4; K74; KB37; Keratin; Keratin-5c; Keratin-74; KRT5C; KRT6IRS4; Krt74; type II cytoskeletal 74; Type II inner root sheath-specific keratin-K6irs4; Type-II
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KRT74
交叉反应：Human, Mouse, Dog, Sheep,
细胞定位：
细胞角蛋白74抗体产品介绍：background: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009] Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. Subunit: Heterotetramer of two type I and two type II keratins. Tissue Specificity: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in细胞角蛋白74抗体 the IRS Huxley layer, but not in Henle layer or cuticle of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed 'Fluegelzellen, along the area of differentiated Henle cells (at protein level). DISEASE: Defects in KRT74 are a cause of woolly hair autosomal dominant (ADWH) [MIM:194300]. A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is 细胞角蛋白74抗体observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrexis nodosa and tapered ends. Similarity: Belongs to the intermediate filament family. Gene ID: 121391 Database links: Entrez Gene: 121391 Human Omim: 608248 Human SwissProt: Q7RTS7 Human Unigene: 660125 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞角蛋白74抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid