跨膜蛋白KREMEN2抗体
规格：1mg/1ml
英文名： KREMEN2
别名： Dickkopf receptor 2; KREM2_HUMAN; KREMEN 2; Kremen protein 2; Kremen protein 2 precursor; Kremen2; Kringle containing protein marking the eye and the nose; Kringle containing transmembrane protein 2;
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KREMEN2
交叉反应：Human, Mouse, Rat, Dog, Sheep,
细胞定位：细胞膜
产品介绍：background: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions 跨膜蛋白KREMEN2抗体interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript跨膜蛋白KREMEN2抗体 variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane. Subcellular Location: Membrane. Similarity: Contains 1 CUB domain. 跨膜蛋白KREMEN2抗体Contains 1 kringle domain. Contains 1 WSC domain. Gene ID: 79412 Database links: Entrez Gene: 79412 Human Entrez Gene: 73016 Mouse Entrez Gene: 287102 Rat Omim: 609899 Human SwissProt: Q8NCW0 Human SwissProt: Q8K1S7 Mouse Unigene: 661128 Human Unigene: 221319 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产跨膜蛋白KREMEN2抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞类型标志物 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid