KPNA4蛋白抗体
规格：1mg/1ml
英文名： KPNA4
别名： FLJ31113; IMA4_HUMAN; Importin alpha 3; Importin alpha 4 subunit; Importin alpha Q1; Importin subunit alpha 3; Importin subunit alpha-4; IPO A3; IPOA 3; IPOA3; Karyopherin alpha 4 (importin alpha 3);
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KPNA4
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse,
细胞定位：细胞浆
KPNA4蛋白抗体产品介绍：background: The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008] Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanismKPNA4蛋白抗体. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by KPNA4蛋白抗体recognizing a nonclassical NLS. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes. Similarity: Belongs to the importin alpha family. Contains 10 ARM repeats. Contains 1 IBB domain. Gene ID: 3840 Database links: Entrez Gene: 3840 Human Entrez Gene: 535090 Cow Entrez Gene: 478680 Dog Entrez Gene: 100171548 Orangutan Entrez Gene: 100349259 Rabbit Entrez Gene: 702486 Rhesus monkey Omim: 602970 Human SwissProt: O00629 Human Unigene: 288193 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KPNA4蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid