组蛋白H3 K79甲基转移酶抗体
规格：1mg/1ml
英文名： KMT4
别名： Disrupter of telomere silencing protein 1; DOT 1; DOT1; DOT1 like; DOT1 like histone H3 methyltransferase (S. cerevisiae); DOT1 like histone H3 methyltransferase; DOT1 like protein; DOT1, S. cerevisia
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KMT4
交叉反应：Human, Mouse, Rat, Cow, Sheep, African Green Monkey
细胞定位：细胞核
组蛋白H3 K79甲基转移酶抗体产品介绍：background: The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011] Function: The KMT4 / Dot1 (disruptor of telomeric silencing) family are a class of histone methyltransferases that play an indirect role in chromatin silencing by targeting a conserved lysine residue in the nucleosome core. Biochemical studies组蛋白H3 K79甲基转移酶抗体 suggest that recombinant Dot1 proteins are active on recombinant nucleosomes, free of any modifications. Subunit: Interacts with MLLT10. Subcellular Location: Nuclear Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily组蛋白H3 K79甲基转移酶抗体. DOT1 family. Contains 1 DOT1 domain. Gene ID: 84444 Database links: Entrez Gene: 84444 Human Entrez Gene: 362831 Rat Omim: 607375 Human SwissProt: Q8TEK3 Human Unigene: 713641 Human Unigene: 228827 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白H3 K79甲基转移酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid