KLRA2蛋白抗体
规格：1mg/1ml
英文名： KLRA2
别名： Ly49-b; Killer cell lectin-like receptor 2; Klra2; KLRA2_MOUSE; Ly-49b; Ly49-b; Ly49b; Lymphocyte antigen 49b; T-cell surface glycoprotein Ly-49B.
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse KLRA2
交叉反应：Mouse,
细胞定位：细胞膜
KLRA2蛋白抗体产品介绍：background: The gene is a member of the large lectin-like type 2 transmembrane receptor family of the natural killer gene complex. The gene is located distantly telomeric to its family's gene cluster on chromosome 6. The gene differs from the other genes in its cluster as its promoter region contains long and short interspersed repetitive elements suggesting a possible rearrangement or gene conversion. It is unknown whether this gene's encoded protein is involved with natural killer cell differentiation as are its other family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010] Function: KLRA2 (also known as Ly49B) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified asKLRA2蛋白抗体 either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA2 is thought to be an inhibitory receptor and associates with the protein KLRA2蛋白抗体tyrosine phosphatases SHP1, SHP2, and SHIP in transfected cells. Subunit: Homodimer; disulfide-linked. Subcellular Location: Membrane; Single-pass type II membrane protein. Similarity: Contains 1 C-type lectin domain. Gene ID: 16633 Database links: Entrez Gene: 16633 Mouse Entrez Gene: 494194 Rat SwissProt: Q60660 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KLRA2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞膜受体 **细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid