肝癌相关抗原33抗体
规格：1mg/1ml
英文名： KLHDC2
别名： HCLP-1; Hepatocellular carcinoma-associated antigen 33; Host cell factor homolog LCP; Host cell factor-like protein 1; Kelch domain containing 2; Kelch domain-containing protein 2; KLDC2_HUMAN; KLHDC2
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KLHDC2
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
肝癌相关抗原33抗体产品介绍：background: KLHDC2 is a 406 amino acid protein that contains six kelch repeats. Localizing to the nucleus, KLHDC2 is widely expressed, with high levels found in muscle, heart, pancreas and liver. KLHDC2 interacts directly with CREB3, repressing CREB3-mediated transcription. Existing as two alternatively spliced isoforms, the gene encoding KLHDC2 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also肝癌相关抗原33抗体 located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. Function: Represses CREB3-mediated transcription by interfering with CREB3-DNA binding. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes. Similarity: Contains 6 Kelch repeats. Gene ID: 23588 Database links: Entrez Gene: 23588 Human Entrez Gene: 69554 Mouse Entrez肝癌相关抗原33抗体 Gene: 299113 Rat Omim: 611280 Human SwissProt: Q9Y2U9 Human SwissProt: Q4G5Y1 Mouse SwissProt: Q3KRE6 Rat Unigene: 509264 Human Unigene: 234368 Mouse Unigene: 129179 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肝癌相关抗原33抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid