TRIM37蛋白抗体
规格：1mg/1ml
英文名： TRIM37
别名： E3 ubiquitin protein ligase TRIM37; E3 ubiquitin-protein ligase TRIM37; KIAA0898; MUL; MUL protein; Mulibrey nanism gene; Mulibrey nanism protein; POB 1; POB1; RING B box coiled coil protein; TEF 3; T
分子量： 108kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRIM37
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
TRIM37蛋白抗体产品介绍：background: TRIM37 is a protein that localizes to peroxisomes and contains a tripartite motif (TRIM) and a tumor necrosis factor-receptor associated factor (TRAF) domain. The protein and gene forms of TRIM37 are highly conserved between human and mouse. TRIM37 is expressed at a low level in the liver, ovary, heart, lung, skeletal muscle, and kidney, while it is highly expressed in the testis and brain, where it may act as an E3 ubiquitin ligase. Mutations in the TRIM37 gene result in Mulibrey nanism, an autosomal recessive prenatal-onset growth disorder that causes characteristic dysmorphic craniofacial features, heart disease, cardiopathy, failure of sexual maturation, TRIM37蛋白抗体and hepatomegaly. Function: E3 ubiquitin-protein ligase. Subcellular Location: Cytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. Tissue Specificity: Ubiquitous. Post-translational modifications: Auto-ubiquitinated. DISEASE: Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and TRIM37蛋白抗体constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common. Similarity: Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 MATH domain. Contains 1 RING-type zinc finger. Gene ID: 4591 Database links: Entrez Gene: 4591 Human Omim: 605073 Human SwissProt: O94972 Human Unigene: 579079 Human Unigene: 605697 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TRIM37蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid