拓扑异构酶相关功能蛋白4-2抗体
规格：1mg/1ml
英文名： TRF4-2
别名： PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; Topoisomerase related function protein 4-2; TRF4-2; PAPD5_HUMAN; TUTase 3.
分子量： 63kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRF4-2
交叉反应：Human,
细胞定位：细胞核
拓扑异构酶相关功能蛋白4-2抗体产品介绍：background: Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion Function: Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the 拓扑异构酶相关功能蛋白4-2抗体degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. Subunit: Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome 拓扑异构酶相关功能蛋白4-2抗体regulatory complex consisting of an helicase Subcellular Location: Nuclear Similarity: Belongs to the DNA polymerase type-B-like family. Contains 1 PAP-associated domain. Gene ID: 64282 Database links: Entrez Gene: 64282 Human Omim: 605540 Human SwissProt: Q8NDF8 Human Unigene: 514342 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
拓扑异构酶相关功能蛋白4-2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid