干扰素调节因子2结合蛋白1抗体
规格：1mg/1ml
英文名： IRF2BP1
别名： DKFZp434M154; I2BP1_HUMAN; Interferon regulatory factor 2 binding protein 1; Interferon regulatory factor 2-binding protein 1; IRF 2BP1; IRF-2-binding protein 1; IRF-2BP1; IRF2 binding protein 1; Irf2
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IRF2BP1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
干扰素调节因子2结合蛋白1抗体产品介绍：background: IRF-2BP1 is a 584 amino acid nuclear protein belonging to the IRF-2BP family. IRF-2BP1 acts as a corepressor of IRF-2 that can inhibit both enhancer-activation and basal transcription in a manner that is not dependent upon histone deacetylation. IRF-2BP1 enhances the polyubiquitination of JDP2 (Jun-dimerization protein 2), a member of the c-Jun family of transcription factors. IRF-2BP1 contains a C-terminal RING-type zinc finger domain, which is necessary for interaction with BAP1 (BRCA1 associated protein 1). IRF-2BP1 is encoded by a gene located on human chromosome 19, which consists of over 63 million bases, houses approximately 干扰素调节因子2结合蛋白1抗体1,400 genes and is recognized for having the greatest gene density of the human chromosomes. Function: Acts as a transcriptional repressor. Acts as a transcriptional corepressor in a IRF2-dependent manner. This repression is not mediated at least in part by histone deacetylase activities. Subcellular Location: Nucleus. Similarity: Belongs to the IRF2BP family. Gene ID: 26145 Database links: Entrez Gene:干扰素调节因子2结合蛋白1抗体 26145 Human Entrez Gene: 272359 Mouse Entrez Gene: 308404 Rat SwissProt: Q8IU81 Human SwissProt: Q8R3Y8 Mouse Unigene: 515477 Human Unigene: 274237 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
干扰素调节因子2结合蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid