Ran结合蛋白11抗体
规格：1mg/1ml
英文名： IPO11
别名： Imp11; Importin 11; Importin-11; IPO11; IPO11_HUMAN; Ran binding protein 11; Ran-binding protein 11; RanBP11; SLRN; Synleurin.
分子量： 107kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IPO11
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：细胞核 细胞浆
Ran结合蛋白11抗体产品介绍：background: Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008] Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from theRan结合蛋白11抗体 nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12. Subcellular Location: Cytoplasm. Nucleus. Similarity: Belongs to the importin beta family. Contains 15 HEAT repeats. Contains 1 importin N-terminal domain. Gene ID: 51194 Database links: Entrez Gene: 51194 Human Entrez Gene: 76582 Mouse Entrez Gene: Ran结合蛋白11抗体310056 Rat Omim: 610889 Human SwissProt: Q9UI26 Human SwissProt: Q8K2V6 Mouse Unigene: 482269 Human Unigene: 132208 Mouse Unigene: 482687 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Ran结合蛋白11抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid