DNA解旋酶INO80抗体
规格：1mg/1ml
英文名： INO80
别名： DNA helicase INO80; hINO80; homolog of yeast INO80; INO80; INO80 complex subunit A; INO80 homolog; INO80_HUMAN; INO80A; INOC1; KIAA1259; Putative DNA helicase INO80 complex homolog 1.
分子量： 177kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human INO80
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Monkey, Macaque Monkey
细胞定位：细胞核 细胞浆
DNA解旋酶INO80抗体产品介绍：background: This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Function: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to DNA解旋酶INO80抗体be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. Subcellular Location: Nucleus. Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner. Tissue Specificity: According to PubMed:10574462, widely expressed. According to DNA解旋酶INO80抗体PubMed:16298340, specifically expressed in brain, liver and pancreas. Similarity: Belongs to the SNF2/RAD54 helicase family. Contains 1 DBINO domain. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Gene ID: 54617 Database links: Entrez Gene: 54617 Human Entrez Gene: 68142 Mouse Omim: 610169 Human SwissProt: Q9ULG1 Human SwissProt: Q6ZPV2 Mouse Unigene: 292949 Human Unigene: 330496 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DNA解旋酶INO80抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid