磷酸化信号转导和转录激活因子5a抗体
规格：1mg/1ml
英文名： phospho-STAT5a (Tyr694)
别名： STAT5 (phospho Y694); p-STAT5 (phospho Y694); STAT5A(Phospho-Tyr694); Mammary gland factor; Mammary gland factor; MGF; MGF; Signal transducer and activator of transcription 5A; Signal transducer and a
分子量： 91kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from rat S
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
磷酸化信号转导和转录激活因子5a抗体产品介绍：background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq, Jul 2008] Function: Carries out a dual function: signal transduction 磷酸化信号转导和转录激活因子5a抗体and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. Subunit: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7. Interacts with ERBB4 (By similarity). Subcellular Location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Mostly cytoplasmic during pregnancy, whereas it becomes predominantly nuclear during early lactation. It is translocated into the nucleus in response to phosphorylation (By similarity). Tissue Specificity: Expressed in heart, lung, and weakly in muscle. Post-translational modifications: Tyrosine phosphorylated in response to IL2, IL3, IL7, IL15, KITLG/SCF, CSF2/GMCSF, GH1, PRL, EPO and THPO. Tyrosine phosphorylated in response to signaling via activated磷酸化信号转导和转录激活因子5a抗体 FLT3 and KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Alternatively, can be phosphorylated by JAK2 at Tyr-694. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Similarity: Belongs to the transcription factor STAT family. Contains 1 SH2 domain. Gene ID: 24918 Database links: Entrez Gene: 6776 Human Entrez Gene: 20850 Mouse Entrez Gene: 24918 Rat Omim: 601511 Human SwissProt: P42229 Human SwissProt: P42230 Mouse SwissProt: Q62771 Rat Unigene: 437058 Human Unigene: 277403 Mouse Unigene: 154399 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子（Transcriptin Regulators）
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：染色质和核信号 信号转导 表观遗传学
磷酸化信号转导和转录激活因子5a抗体储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid