TSN蛋白抗体
规格：1mg/1ml
英文名： Translin
别名： BCLF 1; BCLF1; Component 3 of promoter of RISC; RCHF1; recombination hotspot associated factor; recombination hotspot binding protein; rehf 1; REHF1; TBRBP; Translin; TRSLN; TSN; TSN_HUMAN.
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Translin
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：细胞核 细胞浆
TSN蛋白抗体产品介绍：background: This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by TSN蛋白抗体RefSeq, May 2012] Function: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Subunit: Ring-shaped heterooctamer of six TSN and two TSNAXTSN蛋白抗体 subunits, DNA/RNA binding occurs inside the ring. Subcellular Location: Cytoplasm. Nucleus Similarity: Belongs to the translin family. Gene ID: 7247 Database links: Entrez Gene: 7247 Human Entrez Gene: 22099 Mouse Entrez Gene: 60381 Rat Omim: 600575 Human SwissProt: Q15631 Human SwissProt: Q62348 Mouse Unigene: 75066 Human Unigene: 426637 Mouse Unigene: 435639 Mouse Unigene: 156195 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TSN蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid