锌指蛋白675抗体
规格：1mg/1ml
英文名： ZNF675
别名： FLJ36350; TBZF; TIZ; TRAF6-binding zinc finger protein; TRAF6-inhibitory zinc finger protein; Zinc finger protein 675; ZN675_HUMAN; ZNF 675; ZNF675.
分子量： 66kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZNF675
交叉反应：Human,
细胞定位：细胞核
锌指蛋白675抗体产品介绍：background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. TBZF (TRAF6-inhibitory zinc finger protein), also known as Zinc finger protein 675, is a 568 amino acid nuclear protein that contains one KRAB domain and fifteen C2H2-type zinc fingers. Through modulation of TRAF6 signaling activity and inhibition of RANK signaling, TBZF may play a role in osteoclast differentiation. 锌指蛋白675抗体TBZF is regulated during differentiation of human peripheral blood monocytes into osteoclasts and transfection of TBZF into RAW264.7 cells reduces RANK ligand-induced osteoclastogenesis. Function: May be involved in transcriptional regulation. May play a 锌指蛋白675抗体role during osteoclast differentiation by modulating TRAF6 signaling activity. Subunit: Interacts with TRAF6. Subcellular Location: Nucleus (Probable). Similarity: Contains 15 C2H2-type zinc fingers. brContains 1 KRAB domain. Gene ID: 171392 Database links: Entrez Gene: 171392 Human SwissProt: Q8TD23 Human Unigene: 264345 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白675抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid