人类疱疹病毒8 ORF62抗体
规格：1mg/1ml
英文名： HHV8 ORF62
别名： HHV8; Human herpes virus 8; VP19_HHV8P; Kaposi's sarcoma associated herpesvirus; KSHV; ORF62.
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HHV8 ORF
交叉反应：Human herpesvirus 8
细胞定位：
人类疱疹病毒8 ORF62抗体产品介绍：background: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely 人类疱疹病毒8 ORF62抗体also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23. Function: Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of the major capsid protein ORF25, which are linked together by heterotrimers called triplex. These triplex are formed by a single molecule of VP19C and two copies of VP23 which bridge major capsid protein ORF25 multimers together. Triplexes occupy the local threeflod positions between hexons人类疱疹病毒8 ORF62抗体 and between hexamers and pentamers. Additionally, VP19C is required for efficient transport of VP23 to the nucleus, which is the site of capsid assembly. Subunit: Interacts with VP23, protein ORF25 and ORF19. Subcellular Location: Virion. Host nucleus. Similarity: Belongs to the herpesviridae VP19C family. Database links: http://www.ncbi.nlm.nih.gov/protein/550600169 UniProtKB/Swiss-Prot: F5H8Y5.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
人类疱疹病毒8 ORF62抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid