人类疱疹病毒8 G蛋白偶联受体抗体
规格：1mg/1ml
英文名： HHV8 GPCR
别名： Human Herpesvirus 8 GPCR; VGPCR_HHV8P; Kaposi's sarcoma-associated herpesvirus GPCR; KSHV GPCR.
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HHV8 GPC
交叉反应：Human Herpesvirus 8
细胞定位：
人类疱疹病毒8 G蛋白偶联受体抗体产品介绍：background: Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8, HHV8), is a gamma herpesvirus that contain an open reading frame encoding a G protein-coupled receptor (GPCR) with putative 7 transmembrane domains. This GPCR has been shown to bind a number of chemokines including IL8, NAP2, PF4, MGSA/Gro alpha, I309, RANTES, MCP1, and MIP1 beta. The receptor is constitutively activated without chemokine binding, and it stimulates cell proliferation. KSHV GPCR is also a viral oncogene that stimulates angio-genesis through induction of VEGF expression. IP10, a chemokine, can inhibit constitutively activated KSHV GPCR.人类疱疹病毒8 G蛋白偶联受体抗体 Function: Receptor that signals constitutively via several signaling pathways including PI3K/AKT as well as mitogen- and stress-activated/MAP kinases. Promotes host cell proliferation and survival, modulates cell migration, stimulates angiogenesis,人类疱疹病毒8 G蛋白偶联受体抗体 and recruits inflammatory cells, both in expressing cells and in neighboring cells. Subunit: Interacts with protein K7; this interaction promotes vGPCR proteasomal degradation. Subcellular Location: Host cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
人类疱疹病毒8 G蛋白偶联受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid