转录因子HRT3抗体
规格：1mg/1ml
英文名： Hey L
别名： bHLHb33; Class B basic helix loop helix protein 33; Class B basic helix-loop-helix protein 33; Hairy enhancer of split related with YRPW motif like; Hairy related transcription factor 3; Hairy-related
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Hey L
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
转录因子HRT3抗体产品介绍：background: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Function: Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional转录因子HRT3抗体 repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Subcellular Location: Nucleus. Similarity: Belongs to the HEY family. Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange domain. Gene ID: 26508 Database links: Entrez Gene: 26508 Human Entrez 转录因子HRT3抗体Gene: 538609 Cow Entrez Gene: 56198 Mouse Entrez Gene: 313575 Rat SwissProt: Q2NL18 Cow SwissProt: Q58CQ8 Cow SwissProt: Q9NQ87 Human SwissProt: Q9DBX7 Mouse Unigene: 472566 Human Unigene: 103615 Mouse Unigene: 22252 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录因子HRT3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 神经生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid