磷酸化钙/钙调素依赖蛋白激酶2α抗体
规格：1mg/1ml
英文名： Phospho-CaMKII (Thr286)
别名： phospho-CaMK2 alpha (Thr286); phospho-CaMK2 α (Thr286);CaMKII(Phospho-Thr286); alpha CaMKII; Calcium / Calmodulin Dependent Protein Kinase II G; Calcium calmodulin dependent protein kinase CaM kinase
分子量： 54kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Chicken, Rabbit, Sheep,
细胞定位：细胞膜
磷酸化钙/钙调素依赖蛋白激酶2α抗体产品介绍：background: Ca2+/CalmodulinDependent Protein Kinase II (CaM Kinase II) is a multifunctional calcium and calmodulindependent protein kinase that mediates cellular responses to a wide variety of intercellular signals. CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+homeostasis. Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning. Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. Subunit: CAMK2 is composed of four different chains: 磷酸化钙/钙调素依赖蛋白激酶2α抗体alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1. Subcellular Location: Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse. Note=Postsynaptic lipid rafts. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain. Gene ID: 815 Database links: Entrez Gene: 282162 Cow Entrez Gene: 525416 Cow Entrez Gene: 530719 Cow Entrez Gene: 532713 Cow Entrez Gene: 815 Human Entrez Gene: 816 Human Entrez Gene: 817 Human 磷酸化钙/钙调素依赖蛋白激酶2α抗体Entrez Gene: 818 Human Entrez Gene: 108058 Mouse Entrez Gene: 12322 Mouse Entrez Gene: 12323 Mouse Entrez Gene: 12325 Mouse Entrez Gene: 171140 Rat Entrez Gene: 24245 Rat Entrez Gene: 24246 Rat Entrez Gene: 25400 Rat Omim: 114078 Human SwissProt: Q2HJF7 Cow SwissProt: Q3MHJ9 Cow SwissProt: Q13554 Human SwissProt: Q13555 Human SwissProt: Q13557 Human SwissProt: Q9UQM7 Human SwissProt: P11798 Mouse SwissProt: P28652 Mouse SwissProt: Q6PHZ2 Mouse SwissProt: Q923T9 Mouse SwissProt: P08413 Rat SwissProt: P11275 Rat SwissProt: P11730 Rat SwissProt: P15791 Rat Unigene: 725992 Human Unigene: 131530 Mouse Unigene: 107499 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化钙/钙调素依赖蛋白激酶2α抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 神经生物学 信号转导 激酶和磷酸酶 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid