磷酸化肌肉型6磷酸果糖激酶/磷酸果糖激酶1抗体
规格：1mg/1ml
英文名： phospho-PFKM/PFK1 (Ser775)
别名： PFKM (phospho S775); PFKM (phospho Ser775); p-PFKM (Ser775); Fructose 6 Phosphate Kinase; 6 Phosphofructokinase Muscle Type; GSD7; PFKA; PFK-A; PFKP; PFKX; Phosphofructo 1 Kinase Isozyme A; Phosphofru
分子量： 86kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
磷酸化肌肉型6磷酸果糖激酶/磷酸果糖激酶1抗体产品介绍：background: Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009] Function: Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP. Subunit: Homo- and heterotetramers. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. Interacts (via C-terminus) with HK1 (via N-terminal spermatogenic cell-specific region) Subcellular Location:磷酸化肌肉型6磷酸果糖激酶/磷酸果糖激酶1抗体 Cytoplasm. Post-translational modifications: GlcNAcylation decreases enzyme activity. DISEASE: Glycogen storage disease 7 (GSD7) [MIM:232800]: A metabolic disorder characterized by exercise intolerance with associated nausea and vomiting, muscle cramping, exertional myopathy and compensated hemolysis. Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after vigorous exercise. Similarity: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. 磷酸化肌肉型6磷酸果糖激酶/磷酸果糖激酶1抗体Eukaryotic two domain clade 'E' sub-subfamily. Gene ID: 5213 Database links: Entrez Gene: 506544 Cow Entrez Gene: 403849 Dog Entrez Gene: 100034116 Horse Entrez Gene: 5213 Human Entrez Gene: 18642 Mouse Entrez Gene: 733601 Pig Entrez Gene: 100345647 Rabbit Entrez Gene: 65152 Rat Omim: 610681 Human SwissProt: Q0IIG5 Cow SwissProt: Q60HD9 Cynomolgus Monkey SwissProt: P52784 Dog SwissProt: Q867C9 Horse SwissProt: P08237 Human SwissProt: P47857 Mouse SwissProt: Q2HYU2 Pig SwissProt: P00511 Rabbit SwissProt: P47858 Rat Unigene: 75160 Human Unigene: 272582 Mouse Unigene: 11004 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化肌肉型6磷酸果糖激酶/磷酸果糖激酶1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid