锌指蛋白ZNF265抗体
规格：1mg/1ml
英文名： ZRANB2
别名： ZRANB 2; DKFZp686J1831; DKFZp686N09117; FLJ41119; OTTHUMP00000011240; OTTHUMP00000011241; ZRAB2_HUMAN; Zinc finger protein 265; Zinc finger RAN binding domain containing 2; Zinc finger Ran binding dom
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZRANB2
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
锌指蛋白ZNF265抗体产品介绍：background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2∫ (transformer-2 beta) transcripts and is thought to interfere with constitutive 5’-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. 锌指蛋白ZNF265抗体Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR. Function: ZRANB2 is a splice factor required for alternative splicing of SFRS10/TRA2B transcripts. It may interfere with constitutive 5'-splice site selection. Subunit: Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1. Subcellular Location: Nuclear Post-translational modifications: Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably锌指蛋白ZNF265抗体 by ATM or ATR. Similarity: Belongs to the ZRANB2 family. Contains 2 RanBP2-type zinc fingers. Gene ID: 9406 Database links: Entrez Gene: 9406 Human Entrez Gene: 53861 Mouse Entrez Gene: 58821 Rat Omim: 604347 Human SwissProt: O95218 Human SwissProt: Q9R020 Mouse SwissProt: O35986 Rat Unigene: 194718 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白ZNF265抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid